Rams vs. 49ers: Game day info, betting spread, and how to watch

Mandatory Credit: Cary Edmondson-USA TODAY Sports
Mandatory Credit: Cary Edmondson-USA TODAY Sports /

The LA Rams are 2-1 and now face perhaps their greatest challenge of the young season, the San Francisco 49ers. This game is incredibly important to both teams. The NFC West Division is bunched up right now. With wins to both the Arizona Cardinals and the Seattle Seahawks, a victory by the LA Rams will give the Rams an early lead in the division. Not only will the Rams take a 3-1 record into Week 5, but the Rams will rise to 2-0 in divisional games, which gives them the pole position for any future tiebreakers needed to sort out NFC Playoff berths.

The San Francisco 49ers have their own interests in mind though. A win in Week 4 will not only erase all of their early season struggles from everyone’s mind, but even at 2-2, they will be 2-0 in the NFC West Division, and will themselves be privy to the high ground if and when tiebreakers are necessary to determine playoff seeding.

LA Rams Injury Report vs 49ers Week 4


  • OC Brian Allen (Knee) – Out
  • WR Van Jefferson (Knee) – IR
  • DB David Long Jr. (Groin) – Out
  • DB Cobie Durant (Hamstring) – Out
  • OG David Edwards (Concussion) – Out


  • LB Azeez Al-Shaair (Knee) – Out
  • WR Danny Gray (Hip) – Doubtful
  • RB Tyrion Davis-Price (Ankle) – Out
  • TE  Tyler Kroft (Knee) – Out
  • OT Trent Williams (Ankle) – Out
  • DB Tarvarius Moore (Hamstring) – Out
  • DT Arik Armstead (Foot) – Questionable
  • TE Ross Dwelley (Hamstring) – Questionable
  • DT Javon Kinlaw (Knee)- Questionable

The 49ers had lost to the Chicago Bears in the opener but rebounded nicely to defeat the Seattle Seahawks in Week 2. The 49er then traveled to Denver, where the Broncos would defeat them. The 49ers are undefeated at home this season, and winless on the road. Unfortunately for the Rams, this game is at San Francisco.

Rams vs 49ers Betting Odds, Spread, Over/Under & Betting Pick Week 4

We used WynnBET to find the latest odds and spread for this one.

Point Spread

  • Rams +2.0 (-110)
  • 49ers -2.0 (-110)

Money Line

  • Rams +110
  • 49ers -120

Over/Under – 42.0 points

  • Over -110
  • Under -110

Recommended Bets:

Wow. If this were any team besides the 49ers, I would be grabbing all my cash to place a stake on this one. But after that successive string of losses to the 49ers, I am content to steer clear of the moneyline. In fact, for the first time since including recommendations, I really do not like any of the three options in this one.
Many bookies have set the moneyline for the 49ers at (-130), so if you like to play the hedges, a savvy bet would be to put up the 120 here for the 49ers to win.
Steer clear of this one, but if you must make a bet, here are my very lukewarm recommendations:

Take the Rams with the points (-110) to cover
Take the 49ers on the Money Line (-120) to win
Take the OVER at 42.0 (-110) in this one
National broadcast: ESPN Sports

Whether or not you place a bet, you will undoubtedly be in for a thriller in this one It’s an early game, but it has significant meaning to the NFC West Division and to the NFC Playoff picture overall.

Weather Conditions

The weather at Levi Stadium for this one is about as picture-perfect as you could hope for. The temperature at kickoff will hover on or about 70 degrees with light winds out of the north/northwest. Temperatures will fall to about 63 degrees by the time the final score is posted, so if you are in attendance a light jacket would be a wise accessory.

What TV Channel is the Rams vs 49ers Game On For Week 4?

This game is the second game to be broadcast by ESPN Sports and will air at 5:15 pm PT/8:15 pm ET.

Rams vs 49ers Week 4 Game Live Stream

You can watch this game’s action live by streaming on Fubo TV.

Rams Next Game and Schedule

The LA Rams will next host the surprisingly successful Dallas Cowboys on next Sunday at 1:25 pm on October 9, 2022. Meanwhile, the San Francisco 49ers will travel and play the Carolina Panthers on Sunday, October 9, 2022, at 1:05 pm PT.

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