49ers vs. Rams prediction, odds, spread, injuries, trends for NFL Week 2

A full betting preview for NFL Week 2 action between the Los Angeles Rams and San Francisco 49ers.

Sep 10, 2023; Seattle, Washington, USA; Los Angeles Rams quarterback Matthew Stafford (9) hands the
Sep 10, 2023; Seattle, Washington, USA; Los Angeles Rams quarterback Matthew Stafford (9) hands the / Steven Bisig-USA TODAY Sports

The Los Angeles Rams pulled off one of the bigger upsets in the NFL in Week 1, taking down the Seattle Seahawks in convincing fashion.

Now, they have to take a step up in competition when they host the San Francisco 49ers in Week 2, who are coming off a dominant victory of their own, beating the Pittsburgh Steelers by a score of 30-7.

We're going to break down the odds, trends, and best bet for this NFC West showdown, but if you want my play for every other game this week, you can find it in the latest edition of the "Road to 272 Bets".

If you're going to wager on this week's action, I'd recommend doing it at Caesars Sportsbook. For a limited time, you'll receive $250 in bonus bets when you place your first $50 wager. Just click the link below to take advantage!

Now, let's jump into the game.

49ers vs. Rams odds, spread, and total

49ers vs. Rams betting trends

  • 49ers are 10-2 ATS in their last 12 games
  • 49ers are 7-0 ATS in their last seven games vs. Rams
  • 49ers are 9-1 ATS in their last 10 games against NFC opponents
  • 49ers have won seven straight games against NFC West opponents
  • Rams are 7-2 ATS in their last seven games
  • The UNDER is 5-2 in the last seven meetings between these two teams

49ers vs. Rams injury reports

San Francisco 49ers injury report

  • Robert Beal Jr. - DE - IR (hamstring)

Los Angeles Rams injury report

  • Stetson Bennett - QB - Questionable
  • Cooper Kupp - WR - IR (hamstring)
  • Hunter Long - TE - IR (thigh)

49ers vs. Rams how to watch

  • Date: Sunday, Sept. 17
  • Game Time: 4:05 p.m. EST
  • Venue: SoFi Stadium
  • How to Watch (TV): FOX
  • San Francisco 49ers Record: 1-0
  • Los Angeles Rams Record: 1-0

49ers vs. Rams key players to watch

San Francisco 49ers

Christian McCaffrey: There's no doubt that CMC is the MVP of this team. He carried the 49ers on his back their way to a destruction of the Steelers. He ran for 152 yards and a touchdown while adding on three receptions for 17 yards. San Francisco will go as far as McCaffrey will take it.

Los Angeles Rams

Puka Nacua: While everyone else was focused on the other rookies this year, like Bryce Young and Anthony Richardson, the 5th Round selection from BYU decided to have the best performance of the week. He hauled in 10-of-15 targets for 119 yards. It's only been one week, but he's already doing a more than acceptable job filling in for the injured Cooper Kupp. His odds to win Offensive Rookie of the Year have already shifted from 125/1 to 21/1.

49ers vs. Rams prediction and pick

I bet on the Rams to win outright last week as +200 underdogs. While I'm not going to make quite as bold of a call again in Week 2, I am going to back them to cover the 8-point spread as home 'dogs.

I'm much higher on the Rams than most people are. Matthew Stafford reminded everyone last week that he's one of the better quarterbacks in the league, especially now that he's healthy. They also have some solid players on the defensive side of the football, which we should have all expected to continue. This team did just win the Super Bowl two seasons ago.

The 49ers opening week was impressive, but it's important not to overreact too much to that performance. I think Stafford and company can keep this game closer than people expect.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!