Cardinals vs. Rams prediction, odds, spread, injuries, trends for NFL Week 6

A full betting preview for an NFC West matchup between the 1-4 Arizona Cardinals and 2-3 LA Rams from SoFi Stadium
Los Angeles Rams wide receiver Puka Nacua (17)
Los Angeles Rams wide receiver Puka Nacua (17) / Isaiah J. Downing-USA TODAY Sports

It certainly feels like the Arizona Cardinals have exceeded expectations this season and yet, they’re only 1-4 after a 34-20 loss to the Bengals last week. Now, they’ll face the 2-3 Los Angeles Rams who are fighting to keep out of last place in the NFC West. 

Sean McVay’s Rams fought hard in the first half against the Eagles last week, but were held scoreless after halftime in a 23-14 loss. Matthew Stafford has his favorite weapon, Cooper Kupp back, so the Rams could be ready to take off. 

LA is favored in this matchup, but whichever side you bet on, make sure to use this promo from the PointsBet Sportsbook. Just sign up below to take advantage of $1,000 in second chance bets. 

Cardinals vs. Rams odds, spread and total 

Rams and Cardinals Betting Trends

  • Rams are 3-1-1 ATS
  • The UNDER is 3-2 in Rams games
  • Cardinals are 3-2 ATS
  • The OVER is 4-1 in Cardinals games

Cardinals vs. Rams injury reports

Cardinals injury report

  • Dennis Daley - OL - questionable (ankle)
  • Keaontay Ingram - RB - questionable (neck)
  • Jonathan Ledbetter - DL - questionable (finger)
  • Kelvin Beachum - OL - questionable (hand)
  • James Conner - RB - Out indefinitely (knee)

Rams injury report

  • Joe Noteboom - OL - questionable (groin)
  • Desjuan Johnson - DE - questionable (thumb)
  • Bobby Brown III - NT - out (knee)

Cardinals vs. Rams how to watch

  • Date: Sunday, October 15
  • Time: 4:25 PM EST
  • Venue: SoFi Stadium
  • How to Watch (TV): FOX
  • Cardinals Record: 1-4
  • Rams Record: 2-3

Cardinals vs. Rams key players to watch


Emari Demercado, RB: James Conner has been a huge key to Arizona’s success on offense, but without him last week, after he got injured, they struggled. Joshua Dobbs threw his first two interceptions of the year and Demercado was tasked with replacing Conner. He ran for 45 yards and a touchdown on 10 carries. 


Cooper Kupp, WR: Last week was Kupp’s first game back from injury, but he didn’t miss a beat. He was targeted 12 times and finished with eight catches for 118 yards. Most importantly he coexisted with Puka Nacua who still had seven catches for 71 yards and a touchdown. 

Cardinals vs. Rams prediction and pick

The Cardinals have been impressive on offense, but that’s all built around the run game and James Conner. Conner has run for 364 yards and two touchdowns while averaging 5.4 yards per carry. The Arizona offense is second in the NFL in yards per rush at 5.5. Now that he's hurt, the offense may fall apart completely.

Last week, without the threat of Conner, Joshua Dobbs turned the ball over twice and Demercado was not as productive with his carries. The Cardinals aren’t built to play from behind and they were chasing the Bengals all day long. This could be another game like that because of Matthew Stafford and Cooper Kupp. 

Arizona is 26th in pass defense and 25th in yards per attempt, allowing 7.2. Last week, the Bengals torched their secondary without a healthy Tee Higgins and the Rams might have an even more impressive receiving corps with a healthy Kupp, Puka Nacua, and Tutu Atwell. 

The Rams are fifth in pass yards and second in pass attempts. Stafford is averaging 7.1 yards per attempt and 290.2 yards a game. They’ll have a big day through the air and win big at home. 

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Game odds refresh periodically and are subject to change