Rams vs. Cardinals prediction, odds, spread, injuries, trends for NFL Week 12

Full betting preview for NFL Week 12 action between the Los Angeles Rams and Arizona Cardinals

October 15, 2023; Inglewood, California, USA; Los Angeles Rams quarterback Matthew Stafford (9)
October 15, 2023; Inglewood, California, USA; Los Angeles Rams quarterback Matthew Stafford (9) / Kyle Terada-USA TODAY Sports

The Los Angeles Rams got back in the win column in Week 11, taking down the Seattle Seahawks by a final score of 17-16. Now they have a chance to complete a second season sweep when they head to Arizona to take on the Cardinals. The Rams beat the Cardinals by a score of 26-9 back in Week 6.

If the Rams can get another win this weekend, they'll be firmly back in the hunt for a playoff spot in the NFC. In this article, I'm going to break down everything you need to know to bet on the game.

Check out this week's edition of the "Road to 272 Bets" to find out my best bet for all 16 NFL Week 12 games.

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Rams vs. Cardinals odds, spread, and total

Rams vs. Cardinals betting trends

  • Rams are 1-5 ATS in their last six games
  • The UNDER is 5-1 in the Rams' last six games
  • Rams are 4-1 ATS in their last five games vs. Cardinals
  • Rams are 12-2 straight up in their last 14 games vs. Cardinals
  • Rams are 8-0 ATS in their last eight games played in Arizona
  • The OVER is 5-0 in the Cardinals' last five home games
  • Cardinals are 0-5 ATS in their last five games vs. NFC West opponents

Rams vs. Cardinals injury reports

Los Angeles Rams injury report

  • Cobie Durant - CB - Questionable
  • Quentin Lake - S - Questionable
  • Ben Skowronek - WR - Questionable
  • Puka Nacua - WR - Questionable
  • Kyren Williams - RB - IR

Arizona Cardinals injury report

  • Michael Wilson - WR - Questionable
  • Zach Pascal - WR - Questionable
  • Jonathan Ledbetter - DE - Questionable
  • Emari Demercado - RB - Questionable
  • Joey Blount - S - Questionable

Rams vs. Cardinals how to watch

  • Date: Sunday, November 26
  • Game Time: 4:05 pm EST
  • Venue: State Farm Stadium
  • How to Watch (TV): FOX
  • Los Angeles Rams Record: 4-6
  • Arizona Cardinals Record: 2-9

Rams vs. Cardinals key players to watch

Los Angeles Rams

Puka Nacua: With Cooper Kupp back on the injury report listed as questionable, it may be time for Puka Nacua to once again step up as the No. 1 option in the passing game. His stats have slowed down compared to their early-season pace, but he's still just 103 yards away from 1,000 receiving yards as a rookie. He hauled in four receptions for 26 yards in Week 6 vs. the Cardinals.

Arizona Cardinals

Kyler Murray: The Cardinals star QB has shown little-to-no rust since returning from injury a couple of weeks ago. If he can continue to trajectory, the Cardinals should feel comfortable moving forward with him as their QB of the future.

Rams vs. Cardinals prediction and pick

I've been betting on the Rams a ton this season, but I think this is the perfect spot for an OVER bet. The Los Angeles receiving core should be able to torch this Cardinals defense that is 29th in opponent dropback EPA, 31st in dropback success rate, and 26th in opponent yards per pass attempt. I have no doubt the Rams can do enough to contribute to this OVER.

Meanwhile, the Cardinals' offense looks like a completely different unit with Kyler Murray at quarterback and the Rams defense continues to be a subpar unit, ranking the bottom half of the NFL in virtually every metric.

Let's set back and root for points in this NFC West showdown.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!