Rams vs. Colts prediction, odds, spread, injuries, trends for NFL Week 4

A full betting preview for the LA Rams and Indianapolis Colts on Sunday at Lucas Oil Stadium after the Rams 19-16 loss on Monday Night Football.
Los Angeles Rams wide receiver Tutu Atwell (5)
Los Angeles Rams wide receiver Tutu Atwell (5) / Albert Cesare/The Enquirer / USA TODAY

It looks like the Indianapolis Colts not only have a quarterback, but also a quality head coach.

Anthony Richardson impressed in Weeks 1 and 2, but last week he was out and Shane Steichen was able to lead the Colts to a win over Baltimore with Gardner Minshew at QB. The Colts lead the AFC South at 2-1 with wins over Houston and the Ravens. 

The Los Angeles Rams definitely have a coach and a quarterback, they just don’t have much else. The undermanned Rams fell to 1-2 on Monday Night against the Bengals and just couldn’t protect Matthew Stafford. 

For a look around the league in Week 4 check out BetSided NFL betting expert Iain MacMillan’s “Road to 272” where he bets every game of the season.

If you’re betting any or every NFL game this week, you can do it with this great promo from the FanDuel Sportsbook. Just sign up below and bet $5 to claim $200 in bonus bets, win or lose. 

Now, let’s take a look at the odds for this matchup. 

Rams vs. Colts odds, spread and total 

Colts vs. Rams Betting Trends

  • Colts are 2-1 ATS
  • The OVER is 2-1 in the Colts' games
  • Rams are 2-0-1 ATS
  • The UNDER is 2-1 in the Rams' games

Rams vs. Colts injury reports

Rams injury report

  • Alaric Jackson - OL - Ques Sun (thigh)
  • Jason Taylor II - DB - Out indefinitely (groin)
  • Stetson Bennett - QB - Out indefinitely (illness)
  • Hunter Long - TE - Out indefinitely (thigh)
  • Cooper Kupp - WR - Out indefinitely (hamstring)

Colts injury report

  • Anthony Richardson - QB - day-to-day (concussion)
  • Ryan Kelly - C - day-to-day (concussion)
  • Evan Hull - RB - Out indefinitely (knee)
  • Jonathan Taylor - RB - Out indefinitely (ankle)

Rams vs. Colts how to watch

  • Date: Sunday, October 1
  • Time: 1:00 PM EST
  • Venue: Lucas Oil Stadium
  • How to Watch (TV): FOX
  • Rams Record: 1-2
  • Colts Record: 2-1

Rams vs. Colts key players to watch


Tutu Atwell, WR: The story for the Rams has been Puka Nacua, who has had a historically good start to his season, but Atwell has been the big-play threat in Los Angeles. Atwell had four catches for 50 yards and a touchdown against Cincinnati on Monday Night Football and had one carry for 22 yards. Atwell has 17 catches for 246 yards and a touchdown this season. 


Zack Moss, RB: Moss certainly isn’t helping Jonathan Taylor’s case to get paid. Moss is averaging 105.0 yards a game and 4.4 yards per carry with a touchdown and a team high 14 first downs this season.

Rams vs. Colts prediction and pick

The Indianapolis Colts did something pretty impressive on Sunday, they beat the Baltimore Ravens and did it while gaining just 3.9 yards per play. Indy was outgained while running 12 more plays than the Ravens in the overtime contest, and benefitted from two Baltimore fumbles.

No team is going to win a lot of games doing that, and no team is going to be able to rely on a kicker hitting four 50+ yard field goals. 

The Rams on the other hand are gaining 5.5 yards per play and 368.0 yards a game which rank ninth and 13th. Their offense is effective because of Matthew Stafford and Sean McVay, but the offensive line is crumbling.

In Week 3, the Bengals sacked Stafford six times, but he won’t be pressured nearly as much this week. The Colts rank 17th in pressure rate at 22.5% and only blitz 17.1% of the time. That’s good news for Stafford and the Rams offense. 

I expect LA to win this one as a road underdog. McVay’s team is 7-3 against the spread in their last 10 games and that dates back to the end of last season when the Rams were barely fielding a full team. 

Follow all Josh Yourish’s bets HERE

Game odds refresh periodically and are subject to change