Rams' gameday roster updates and injury rundown, plus 3 Cardinals to watch

The Los Angeles Rams enter Week 6 against the Arizona Cardinals looking to get back to .500 for the third time this season. Imagine saying that before the season began. Ah, how the winds have changed.

Nonetheless, the game is a get-right opportunity in every sense after the special teams meltdown and porous run defense the Rams put on display against the Buffalo Bills in Week 5. A win would match Seattle at 3-3 in the NFC West, although the 49ers appear to be running away with the division at a perfect 5-0. 

Like last week, LA has the luxury of a light injury report. Only safety Kam Curl (ankle) and cornerback Trent McDuffie (groin) were listed as questionable. Head coach Sean McVay was optimistic about Curl's status when he spoke to the media on Friday. 

McDuffie is more up in the air, and the Rams yesterday elevated cornerback Cam Lampkin from the practice squad. Rookie tackle Keagen Trost was activated from injured reserve for the first time this season, providing insurance behind replacement starter David Quessenberry as left tackle Alaric Jackson serves a one-game suspension.

3 Cardinals for Rams fans to watch in Week 6

Quarterback Jacoby Brissett. Brissett has quietly performed quite well against the Rams in his career. Including two games with Arizona last season, he has completed 57 of 88 passes for 689 yards, six touchdowns, and two interceptions in four appearances. His 101.9 passer rating versus LA is Brissett's fifth-ranked mark against any team. 

With rookie running back Jeremiyah Love ruled out, the Cardinals may have to depend on the passing game more than they'd like. That's good news for the Rams, but Brissett can also be effective with the right gameplan. Don't sleep on him. 

Tight end Trey McBride. McBride has dominated the target share since last season, when he led all tight ends in catches and receiving yards and tied the Eagles' Dallas Goedert with 11 touchdowns. So far this year, he has 42 receptions for 308 yards and a pair of scores. Although now-Texans receiver Marvin Harrison Jr. hadn't been much productive, trading him  away gives Brissett one fewer target to work with. 

With an extra wideout gone, McBride could feature even more heavily as a pass-catcher. The Cardinals also look to use him as an extension of the run game on short-area throws with Love sitting out. 

Edge rusher Josh Sweat. Sweat is not off to a productive start (just one sack versus a career-high 12 last season) but he could have an easier time in this one. Quessenberry will start at left tackle after playing all of 18 offensive snaps last season, and he could match up with Sweat off the edge. 

Although the Cardinals list Sweat as their right-side outside linebacker, in 2025 he split time on either edge. If they want to pick on Quessenberry, they might slide Sweat over to the left more often. 

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